In addition to keyword filters that Blaze mentioned, PieFed is basically the only way I know of, other than an app (Sync or Connect) that offers a true instance filter that blocks all users from the specified instance, without requiring admin support. I’ve blocked all those batshit insane comments from lemmy.ml and now if I go to the same identical posts, those comments from those users from those instances that you specify are flat gone. Regardless of the community. More in this post but that’s basically it that I’ve said already.

Likewise, Categories of Communities allows you to have your cake and (when you want it) eat it too. e.g. check out https://piefed.social/topic/arts-craft and note absence of it, in that category. Likewise https://piefed.social/topic/fediverse, and https://piefed.social/topic/food, and https://piefed.social/topic/gaming, and so on. But, in the very rare event that you ARE wanting it (hey, it happens!) it’s still accessible at https://piefed.social/topic/news (& politics).

I would be remiss if I did not tell you that PieFed isn’t fully completed yet - it both has features that Lemmy (and even Reddit!) lacks, while also missing some, like its search feature is pretty abysmally bad (on purpose, it just hasn’t been the top priority yet, to receive some love and attention:-). Though I still love it even so. You can keep your old account (to do things that PieFed cannot yet), and eventually you should find yourself using the new perhaps 90% of the time, as you adjust and come to love what it can do for you - though note that I find that the approach to finding content is quite different from when I used Lemmy, which only offers Subscribed vs. All, whereas PieFed has so many more options to choose from (it may be overwhelming at first - but it’s so fantastic to have choices!:-).