You can!
Add Steamtinkerlaunch to your steam proton list with protonup‐qt Then, select it under the force compatibility menu. From there, just click the run vortex mod manager button.
You can also run steamtinkerlaunch standalone, which is what I did for cyberpunk2077, but I feel like I did more manual file moving than I had to.
Edit: can’t spell today
What frontend is that?