I mean, give me a knife or screwdriver and it’s equal, but anything that requires extensive practice for basic competence is naturally going to be become focused on one hand (e.g. handwriting) or a specific combination of hands (e.g. you need two hands to play guitar, but people will generally learn to play it either righthanded or lefthanded and suck at the other one regardless of how ambidexterous they are).
Minecraft probably. I avoid legitimate horror games (and movies) and the fact that you don’t have saves can get a little stressful when you’re down in a cave, don’t know how to find your way back (and thus probably won’t find your body) and then basically get jumpscared by dangerous enemies or holes in the ground.